As the nerve action potential gets more and more intense, more ACh is released eventually leading to sufficient ACh landing on the muscle receptors, which then react by changing shape and letting in sodium ions. The inflood of positively charged Sodium ions sets up a new wave of depolarisation in the muscle fibre causing a contraction.

The diagram to the left shows the mechanism of action of Protox-like peptides. Note how two vesicles are releasing Ach into the synapse above but now with Protox added, only one vesicle fuses with the nerve fibre cell wall, thereby reducing the amount of Ach released or another way of looking at it - increasing the amount of stimulation required before muscle contractions occurs.

Advanced Explanation:

Protox contains a small hexapeptide that is designed to partially interfere with the SNARE (which is a ternary complex formed by the proteins VAMP, Syntaxin and SNAP-25) This complex intervenes in the process of docking, fusing and exocytosis of these neuro-transmitter vesicles.

Protox is a mimic of the N-Terminal end of SNAP-25 which can therefore compete for a position in the SNARE complex, thereby modulating it's formation. If the complex is slightly destabilised, the vesicle is not able to release as much neuro-transmitter, thereby muting muscle contraction and helping to prevent the formation & visibility of wrinkles.

Importantly and unlike Botox (Botulinum Toxin A) Protox does not paralyse completely but acts in a very similar way. Both Botox and Protox only acts at the site of application.

PROTOX

DIRECTIONS

USE TWICE DAILY. ONCE IN MORNING AFTER CLEANSING BUT BEFORE ANYTHING ELSE, AND ONCE IN THE EVENING AFTER CLEANSING

INGREDIENTS

LIPOSOMES - are minute spherical capsules comprised of specific lipids, which mimic part of the skins natural structure. Liposomes are able to entrap a number of materials which they then protect. Because of their compatibility with the skins natural lipids the liposomes are able to penetrate deeper into the skin.

ARGIRELINE - ARGIRELINE® is a patented peptide which reduces the depth of wrinkles on the face caused by repeated facial movements, especially in the forehead and around the eyes.

HYALLURONIC ACID - Is a high-molecular naturally occuring material which forms a flexible film on the skin which has the ability to hold large quantities of water helping to effectively moisturise the skin, to help prevent cross-linking.

PML - Minute, multi-layered spheres which entrap active materials, protecting them until they are needed.

The PMLs help to transport the actives through the skin's surface to the lower layers of the skin, where the actives are then slowly released to implant the maximum benefit over a period of time.  

PROTOX - PATENTED ARGIRELINE FORMULATION   - CLINICALLY PROVEN TO REDUCE THE DEPTH OF WRINKLES BY UP TO 50% IN 30 DAYS.

How does it work?

Protox works by relaxing the muscles in the face that otherwise are engaged in making expressions.  These expressions crease the skin and cause lines and wrinkles.  The permanent muscle tone present in many facial muscles make the creases look like deep furrows.

Protox DOES NOT PARALYSE the muscle, it has a gentle effect on the SNARE receptor causing a relaxing effect on muscles not total paralyse.  Used on a regular basis Protox can therefore assist in eliminating the formation of wrinkles and soften and smooth out existing wrinkles. 

Protox is a colourless fragrant -free gel and should be used twice daily  as a treatment prior to using regular skin care products.  Protox incorporates only pharmaceutical grade raw ingredients to ensure best possible results.   

ORIGINAL FORMULA  -  PROTOX 10  SERUM    - for less wrinkled & younger skin - as a maintenance or alternative to muscle paralysing injections

Only Protox contains a unique blend of super-concentrated Argireline (patented) together with Sodium Hyaluronate and Seaweed Extract that causes wrinkles to melt away while hydrating and moisturising the skin.  Protox is formulated with a pharmaceutical grade "Liposome Delivery System" to maximise delivery of the active ingredient into the target ared giving better results ....faster. 

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ADVANCED FORMULA -  PROTOX 20 SERUM  - for more mature, deeper  wrinkled skin - as a maintenance or alternative to muscle paralysing injections.

Only Protox contains a unique blend of super-concentrated Argireline (patented) together with Sodium Hyaluronate and Seaweed Extract that causes wrinkles to melt away while hydrating and moisturising the skin.  Protox is formulated with a pharmaceutical grade "Liposome Delivery System" to maximise delivery of the active ingredient into the target ared giving better results ....faster.